Pfizer Senior Associate Scientist, ImmunoPharmacology Tumor Biology, Cancer Vaccines & ImmunoTx in La Jolla, California
Cancer Vaccines and Immunotherapeutics seeks to discover novel vaccines for the prevention and treatment of various cancers by using a variety of vaccine technology platforms and in combination with immunomodulatory agents. We are searching for a motivated individual with a basic scientific understanding of tumor biology with practical experience in the theory and fit for purpose use of various murine tumor models. The candidate will be required to proactively apply their knowledge to prosecute experimental work plans provided by their supervisor and effectively conduct their work semi- independently and as a member of the ImmunoPharmacology team. The candidate will be required to summarize and critique their results, with guidance from their supervisor, as well as on occasion communicate data effectively at work-group meetings.
This role is laboratory based with a major emphasis placed upon cell culture and executing murine tumor models. The primary role is to maintain and provide tumor cells for tumor implantation models and assist in the execution of murine tumor studies, which are designed to understand/refine the mechanism of action responsible for the preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches.
Tumor Biology Research
With direction, assist other team members in conducting murine tumor models that measure the preclinical efficacy of cancer vaccines and similar immunotherapeutic approaches.
With direction, assist other team members in conducting ex vivo immune assays to study biomarkers and immune responses in murine tumor models
Primary Responsibilities - Laboratory and related work (90 of time) with supervision:
Assist in the design and execution of studies in relevant in vivo immuno-oncology-related models.
Assist in the execution of in vitro/ex vivo assays
Perform cell culture work for tumor implantation models following SOP
Identify and report any experimental problems, troubleshoot causative factors, and suggest necessary corrections in discussion with supervisor.
Support general laboratory operations including daily preparation of buffers and solutions, ordering and re-stocking laboratory supplies, maintaining a clean and safe work environment and maintenance of equipment.
Regularly records experimental work upon completion in electronic notebook systems and archives instrument raw data on server databases.
Communicates effectively with ImmunoPharmacology and Immunology team members.
Actively contributes ideas in group and line meetings.
Provides clear, concise and timely responses for data and experimental information to line manager.
Scientific/ Technical Knowledge
Demonstrated experience in primary and cell line culture
Demonstrated experience in one of the following ex vivo assays: cell based assays preferably immune assays; basic flow cytometry; molecular biology (DNA/RNA extraction; qPCR etc.)
Demonstrated experience in murine models, preferably murine tumor models.
BS in life sciences
3+ years of experience working in a laboratory setting that routinely performs ex vivo and in vivo experiments in murine models.
Practical understanding and application of statistical methods to experimental design and outcome measures.
Highly organized in daily tasks
Good oral and written communication skills
Effective in communication skills both verbal and written; listens and understands well. Excellent interactive skills with people with diverse backgrounds and perspectives.
Proactively recognizes needs and problems, and independently identifies and implements effective steps and solutions
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Lifting, sitting, standing, walking, bending, repetitive pipetting, ability to perform mathematical calculations, ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.
Routine off-hour and weekend schedule
Adherence to La Jolla EHS policies and training; ability to work with human, non-human primate or murine blood samples and organ tissues.
Will be required to work with BSL2 infectious viruses (e.g. Vaccinia virus, adenovirus, and influenza) and must receive and maintain required vaccinations or provide satisfactory proof of same.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Other Job Details:
Last Date to Apply for Job: March 19, 2018
Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.